In the United States (U.S.), Hispanics have the highest prevalence of MASLD and metabolic dysfunction-associated steatohepatitis (MASH), driven in part by a higher population frequency of the PNPLA3 I148M variant, while African Americans have lower rates compared to White people/persons/person (11) (12). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.