The elevated levels of inflammatory factors such as tumor necrosis factor -α (TNF-α) and interleukin-6 (IL-6) in patients with T2DM can activate vascular endothelial cells, promote the expression of adhesion molecules, mediate the adhesion and migration of white blood cells, and accelerate the process of atherosclerosis (20). This evidence concerns the gene IL6 and type 2 diabetes mellitus.