All the compounds synthesized were interestingATX inhibitors with IC50 values below 300 nM, highlightingcompound 96 as the best ATX inhibitor with an IC50 value of 3.4 nM and the most potent antiproliferative compoundin ATX abundant cancer cell lines, especially Hep-3B (0.58 μM)and RAW264.7 (0.63 μM). Here, ENPP2 is linked to cancer.