In researchon neurodegenerative diseases such as Alzheimer’s, derivativeshave been developed with multitarget activities, including the inhibitionof cholinesterases (AChE/BuChE), secretases (BACE1), and modulationof γ-secretase, in addition to showing anti-inflammatory potentialby inhibiting COX-2. Here, BCHE is linked to neurodegenerative disease.