FH and hereditary clear cell renal cell carcinoma: It is thus suggested that 2SC positivity may allow for more sensitive detection of uterine leiomyomas as well [2,12]. Management of FH-deficient leiomyomas, therefore, requires typical surgical removal and/or hormonal therapy in addition to surveillance for genetic counseling and surveillance for renal cell carcinoma, inclusive of annual abdominal imaging (Table 4) [3].