TNF and Cushing syndrome due to macronodular adrenal hyperplasia: Subsequently, we conducted KEGG pathway analysis on the 1460 identified genes and found that these pathways included metabolism, HIF-1 signaling, TNF-α signaling, cGMP-pPKG signaling, Endocytosis, Salmonella infection, Cushing’s syndrome, and protein processing pathways in the endoplasmic reticulum.