TMPRSS2 and infection: ,40,48,49,50,51 Finally, we observed that MLN4924 inhibited the replication of other coronaviruses (SARS-CoV-2, SARS-CoV, and 229E) as well as RNA viruses such as Zika virus35 and Mayaro virus, which do not require TMPRSS2 for infection (Figures 4D, S14, andS15).