Using synthetic and large-scale real tau PET data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (Mueller et al., 2005), and Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) (Sperling et al., 2014) studies, we conduct a series of experiments to demonstrate the much improved generalization performance of the proposed method than the SuStaIn method. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.