Using synthetic and large-scale tau PET imaging data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) studies, we compare with the state-of-the-art SuStaIn method and demonstrate the improved generalization performance of the proposed method. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.