The Alzheimer’s disease mouse model APP/PS1, characterized by the expression of human APP695swe and presenilin 1 (PS1-ΔE9) mutants, presents shorter AIS and reduced ankyrinG levels in early postnatal development due to astrocytes transcriptomic alterations (Benitez et al., 2024). Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.