However, in obesefemales, apelin levels decreased after completing an 8–12‐week exercise program [52, 53] and a meta‐analysis did not identify significant differences in apelinlevels in response to physical activity [54].Given the multiple beneficial effects of apelin that are of particular interest inpatients with T1D, further studies on factors increasing apelin, including exercise, arewarranted. This evidence concerns the gene APLN and type 1 diabetes mellitus.