HIF-1α targeting in evidence of the importance of ginsenosides as anticancer agents is mainly reflected in their mechanisms of action on the regulation of the TME, angiogenesis inhibition, metastasis inhibition, et al. HIF-1α is a core regulator of tumors adapting to the hypoxic microenvironment, especially in solid tumors, where hypoxia activates HIF-1α, which in turn regulates the expression of downstream target genes and promotes malignant tumor progression. Here, HIF1A is linked to cancer.