Findings from this investigation regarding TRPM3 function in individuals with ME/CFS provide further insight into ME/CFS pathomechanisms and are pivotal for advancing not only the development of a diagnostic test but also the identification and treatment based on the restoration of TRPM3 ion channel activity that relieves symptoms and improves QoL. This evidence concerns the gene TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome.