Remarkably, in the ME/CFS cohort of this investigation, cognitive difficulties were reported for all patients except one (97.22%), and sensory disturbances for 32 of 36 participants (88.89%), which is potentially linked to dysregulation of TRPM3 in the CNS of people with ME/CFS given the expression of TRPM3 in the CNS. Here, TRPM3 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.