TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome: In 2016, Marshall-Gradisnik et al. were the first researchers to associate differences in the TRP ion channel with NK cells from ME/CFS, reporting 11 single-nucleotide polymorphisms (SNPs) in TRP ion channel genes (TRPC4, TRPC2, TRPM3, and TRPM8) (27).