The results showed that Age, Temperature, Heart rate, Pulse Oximetry, Lymphocyte, C- reactive protein, SAA, NLR, Tn-T, Pro–BNP, D–DIMER, ALT, ALB, GLU, HLN, Ca, LDH, PCT, IL-6, Pleural effusion and Heart enlargement were associated with poor prognosis in patients with severe Omicron pneumonia (P < 0.05). The gene discussed is GNPDA1; the disease is Pleural effusion.