Furthermore, the established dynamic monitoring system utilizes mechanism-guided biomarkers: serum IL-6 receptor saturation (critical value > 85%) can provide early warning of immunodeficiency states induced by JAK-STAT over-inhibition (72), while plasma D-dimer levels quantify SRC-mediated thrombotic risk associated with vascular endothelial dysfunction (73). Here, SOAT1 is linked to immunodeficiency disease.