,15 In the tumor microenvironment, CD24 on the surface of tumor cells binds to Siglec-10 on macrophages, which misguides macrophage recognition and prevents the initiation of phagocytosis.14, 15, 16,21 CD24 is often overexpressed in various human cancers, including HNSCC/OSCC,15,22, 23, 24, 25 and its expression is positively correlated with poor prognosis.22 The gene discussed is CD24; the disease is head and neck squamous cell carcinoma.