For instance, in models of ischemic stroke, lysine lactylation of the transcriptional regulator MeCP2 at specific sites (K210/K249) has been shown to repress the transcription of pro-apoptotic genes such as Pdcd4 and Pla2g6, effectively attenuating neuronal apoptosis and conferring neuroprotection. Here, MECP2 is linked to ischemic stroke.