Recent research in models of cerebral ischemia and subarachnoid hemorrhage has shown that inhibition of p300, either through genetic knockdown or pharmacological agents such as A-485, results in a marked reduction in lactylation levels, decreased neuronal apoptosis, and attenuated glial activation (Sun et al., 2025; Mi et al., 2025). Here, EP300 is linked to subarachnoid hemorrhage.