TREM2 and Alzheimer disease: We also observed higher brown module lipid levels and lower blue module levels in AD(TREM2+) versus AD(TREM2−) carriers (AD-independent associations), although only the association with the brown module survived multiple testing (beta = 0.958, 95% CI = 0.29–1.64, P = 0.006) (Fig. 2 and Supplementary Table 3).