TREM2 and Alzheimer disease: On the other hand, the decrease in yellow module levels in AD(TREM2−) donors relative to controls was similar to that observed in AD(TREM2+) donors compared to controls (beta = −0.834, 95% CI −1.52 to −0.145, P = 0.019 and beta = −0.03, 95% CI −1.54 to −0.07 P = 0.032, respectively), highlighting no additional effect of TREM2 on lipid levels in the yellow module (TREM2-independent associations).