TREM2 and Atrophy: TREM2-related pathologies include regional brain atrophy, myelin loss, swollen axons in white matter and changes the density and shape of microglia subsets.37,38 TREM2 dysfunction prevents microglia from switching to a glycolytic state39 resulting in deficits in Aβ, myelin debris, apoptotic neuron and E.coli phagocytosis.15,40-43 Results from analysis of very rare TREM2 risk cases are limited.