The hub lipid of the BA9 ‘turquoise’/hippocampus ‘blue’ module, Phosphatidyl-serine [PS(32:1)], was increased in AD versus Control donors (beta = 0.677, 95% CI 0.28–1.08, P = 1.14E−03), and in AD(TREM2+) versus Control donors (beta = 1.00, 95% CI 0.53–1.48, P = 5.57E−03), whereas the strongest association was observed with Ceramide [Cer(d38:1)] increased in AD versus Control donors (beta = 0.929, 95% CI 0.46–1.40, P = 1.67E−04) and in AD(TREM2+) versus Controls donors (beta = 1.31, 95% CI 0.78–1.84, P = 4.35E−06). The gene discussed is TREM2; the disease is Alzheimer disease.