Hence, the intracellular accumulation of unprenylated Rab GTPases is highly indicative of MKD, distinguishing it from other IL-1β-mediated diseases such as Cryopyrin-associated periodic syndromes (CAPS) and Familial Mediterranean fever (FMF) (6, 7) that are caused by variants in NLRP3 or MEFV, respectively. This evidence concerns the gene MEFV and familial Mediterranean fever.