Hemophagocytic lymphohistiocytosis (HLH) is an immune response syndrome marked by aberrant hyperinflammation, hyperferritinemia, and a potentially fatal cytokine storm, marked by persistent activation of CD8+ cytotoxic T lymphocytes and natural killer (NK) cells, leading to increased secretion of inflammatory cytokines and macrophage activation resulting in excessive inflammation and tissue destruction [1, 2]. Here, CD8A is linked to hemophagocytic syndrome.