METTL3 and neoplasm: For example, the Methyltransferase-like 3 (METTL3)-Insulin-like Growth Factor 2 mRNA-Binding Protein 3 (IGF2BP3)-m6A axis enhances angiogenesis, glycolysis and hypoxic adaptation in GC by stabilizing hepatoma-derived growth factor (HDGF) and Hypoxia-Inducible Factor 1 Alpha (HIF1A) mRNA, thereby driving tumor progression and metastasis (Han et al., 2023).