YTHDF1 cooperates with eEF-2 to induce the migration and EMT process of GC cells (Liu et al., 2020); meanwhile, YTHDF2 enhances ferroptosis tolerance via CBSLR and inhibits cell proliferation through FOXC2 signaling, indicating its dual potential of both pro-cancer and anti-cancer and the potential to serve as a prognostic indicator (Yang et al., 2022). The gene discussed is YTHDF2; the disease is cancer.