In the multivariable logistic regression model, the pre-specified predictors (NIHSS score > 15, diabetes, coronary heart disease), the candidate variables with univariate p < 0.10 (infection, AKI, fall history, elevated troponin I, elevated creatinine, elevated CRP, and days from admission to peak CK > 2 days), and the primary exposure (RML group) were included. The gene discussed is CRP; the disease is acute kidney injury.