Interferon (IFN) signaling is essential for anti-tumor immunity by promoting antigen presentation, T cell infiltration, and the expression of effector molecules like PD-L1 and MHC class I. Type I (IFN-α/β) and type II (IFN-γ) IFNs primarily activate the JAK/STAT pathway. Here, IFNA1 is linked to neoplasm.