Supporting this, a 2001 study demonstrated that tumor cells deficient in IFNγ responsiveness could be rendered immunogenic through stable transfection of TAP1, leading to tumor rejection in immunocompetent (wild-type) mice, but not in T cell-deficient (Rag2−/−) animals, highlighting the T cell dependency of this immune response (65). The gene discussed is IFNG; the disease is neoplasm.