HLA-G and neoplasm: To systematically summarize current findings, a literature search was conducted in the PubMed database using the terms “lncRNA or long noncoding RNA or long non-coding RNA, “ “immune suppression or immunosuppressive, “ and “tumor microenvironment.” This review includes studies addressing key immunological checkpoints (PD-L1, TIM-3, HLA-G) and immunosuppressive cell types (Tregs, MDSCs, TAMs) regulated by lncRNAs within the TME.