For example, SIX3/LSD1/NuRD(MTA3) complex suppresses breast cancer initiation and metastatic progression (29); GATA3/G9A/NuRD(MTA3) complex inhibits tumor invasion in both in vitro and in vivo models, and its downregulation leads to ZEB2 upregulation and promotes malignant progression (13). This evidence concerns the gene MTA3 and neoplasm.