In summary, as a key adaptor within the NuRD complex, MTA3 precisely regulates multiple key signaling pathways by directing the recruitment of histone-modifying complexes to specific gene promoters.Its potential holds significant exploratory value and is anticipated to offer novel scientific foundations for the analysis of mechanisms and the development of therapeutic intervention strategies for related diseases, including breast cancer, hematological disorders, and various tumors. Here, MTA3 is linked to breast cancer.