MTA3 and breast carcinoma: For example, SIX3/LSD1/NuRD(MTA3) complex suppresses breast cancer initiation and metastatic progression (29); GATA3/G9A/NuRD(MTA3) complex inhibits tumor invasion in both in vitro and in vivo models, and its downregulation leads to ZEB2 upregulation and promotes malignant progression (13).