However, as emphasized by Alexandra et al., since p16 expression lacks absolute specificity, confirmation of cervical origin for ovarian metastases requires demonstration of either identical chromosomal HPV DNA integration sites or concordant HPV genotypes between ovarian tumors and primary cervical carcinomas (13).Since the cervical adenocarcinoma in this case was an incidental postoperative finding, direct HPV DNA PCR testing was not performed on the surgical specimen. This evidence concerns the gene CDKN2A and ovarian neoplasm.