(59) utilized black cardamom extract to assist in the biosynthesis of zinc oxide nanoparticles (ZnO NPs), which were found to induce ferroptosis in Pre-B ALL cells (Nalm-6 and REH) by significantly reducing the mRNA-level expression of SLC7A11 and GPX4, while upregulating the expression of ACSL4 and ALOX15. This evidence concerns the gene GPX4 and acute lymphoblastic leukemia.