RIPK1 and neoplasm: Building on this pathological evidence, Liu et al. (2016[41]) observed that necroptotic activity was linked to tumor growth and new blood vessel formation, with increased levels of p-MLKL and RIPK1/3/necroptotic activity, along with higher microvessel density and tumor burden, reinforcing the case for pathway inhibition in the presence of the necroptotic program (Liu et al., 2016[41]).