TNFRSF1B and breast neoplasm: TNFR2 interacts with this network by competing with the ligand and adaptor pools and modifying the residency threshold of Complex I. In breast tumors, TNFR2 levels are elevated compared to those in normal tissue, which is associated with increased NF-KB production and promotes growth; its inhibition reduces these signals, while TNFR1 is associated with an apoptotic phenotype (He et al., 2021[24]).