Compared with previously published cases, our case stands out for three reasons: concurrent T1DM and SGLT2 inhibitor use, the severity of acidemia requiring intubation and intravenous bicarbonate therapy, and biochemical evidence of pancreatic stress with markedly elevated amylase levels, suggesting possible tirzepatide‐related pancreatitis. The gene discussed is SLC5A2; the disease is type 1 diabetes mellitus.