ESR1 and breast cancer: The most predictive driver meQTL was associated MSH2, a gene associated with Lynch syndrome and increased risk of breast cancer.19 Polymorphic variation affecting the expression of EZH2, the second most informative feature, has also been linked to breast cancer risk.20 ASXL2 may be required for estrogen receptor alpha (ERa) activation in ERa positive breast cancers.21 Notably, EZH2 overexpression has been linked more strongly to triple negative breast cancer22 suggesting that the model includes features predictive of multiple subtypes.