AKT1 and sarcoma: Among them, FRS2 and phospholipase Cγ (PLCγ) serve as key mediators that activate three canonical signaling cascades: the rat sarcoma/extracellular signal-regulated kinase–mitogen-activated protein kinase (RAS/ERK–MAPK) pathway, the phosphoinositide 3-kinase–protein kinase B (PI3K–AKT) pathway, and the PLCγ pathway.20