Given the similarity between EGFR and FGFR signaling pathways, both of which involve receptor tyrosine kinase activation and PI3K–AKT and ERK–MAPK cascades25,144, it is plausible that FGFR signaling mobilizes a similar complex regulatory network to control RNA splicing regulatory programs contributing to tumor initiation and progression. The gene discussed is PIK3CA; the disease is neoplasm.