Likely in hepatocellular carcinoma, specific lncRNAs recruit polycomb proteins (EZH2, SUZ12) and histone demethylases (KDM2A) to FGFR2 loci, facilitating exon IIIb inclusion and favoring tumor-suppressive isoform expression.287. The gene discussed is EZH2; the disease is hepatocellular carcinoma.