In prostate cancer, a novel splice variant, FGFR3-S, which lacks exon 14 encoding the activation loop of the kinase domain, exhibits increased autophosphorylation and constitutive activation of downstream pathways such as AKT, Signal transducer and activator of transcription 3 (STAT3), and S6 ribosomal protein. The gene discussed is STAT3; the disease is Familial prostate cancer.