Evidence from tumor tissue studies underscores the importance of isoform-specific regulation in diffuse gastric cancer, where ESRP1 is frequently upregulated through gene amplification and promoter hypomethylation, thereby biasing splicing toward the FGFR2-IIIb isoform while suppressing FGFR2-IIIc expression113,.114. Here, ESRP1 is linked to neoplasm.