Hence, aggregates sometimes form within or near the perikarya (neurofibrillary tangles in AD, balloon neurons in Pick’s disease, tufted astrocytes in progressive supranuclear palsy), and sometimes form in their distal processes (tau-positive dystrophic neurites in AD, astrocytic plaques in corticobasal degeneration). Here, MAPT is linked to Classical progressive supranuclear palsy.