Fang et al. (68) reported that NOD-like receptor family pyrin domain containing 3 (NLRP3) is a key component of the inflammasome and is upregulated in patients with CAVD, whereas the expression of suppressor of cytokine signaling 1 (SOCS1) a negative regulator of NLRP3—is significantly reduced. The gene discussed is SOCS1; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.