Peri implant mucositis shows significantly increased levels of IL-1β, aMMP8, procalcitonin, bone turnover marker RANKL and salivary alpha amylase while IL-1β, VEGF, MMP8, Procalcitonin, RANKL, Osteoprotegerin (OPG) are all significantly elevated in peri implantitis. This evidence concerns the gene TNFRSF11B and Peri-Implantitis.