The five most down regulated genes in RSA-PCa blood included ENSG00000287510 (FC: -10.2; lncRNA antisense to the LAPTM5 gene and related to immune function), AGBL3 (FC:-4.16), ENSG00000228748 (FC:-4.1; a lncRNA, associated with cardiovascular function), ENSG00000290680 (FC:-3.8; linked to BMI and obesity) and LINC02470 (FC:-3.8; a lncRNA that regulates bladder tumorigenicity). The gene discussed is LAPTM5; the disease is Obesity.