The five most significantly upregulated genes in RSA-Healthy controls were: IGHG1 (FC: 10.3), IGKV3-15 (FC: 8.6), IFI27 (FC: 8.5), MTCO1P40 (FC: 6.8) and RMRP (FC: 6.6) and the five most downregulated genes included GVINP1 (FC: -574.1), LY75-CD302 (FC: -313.4), ENSG00000263244 (FC: -109.8; a novel transcript, 3' overlapping Chromosome 16 ORF72, associated with obesity and cholesterol metabolism [also downregulated in RSA-PCa vs. USA-PCa]), ENSG00000272410 (FC: -20.0; a novel, uncharacterized protein associated with BMI) and HTATSF1P2 (FC: -17.0). The gene discussed is LY75; the disease is obesity due to melanocortin 4 receptor deficiency.