The five most significant genes that were upregulated in RSA-PCa with the highest fold changes included CERS6-AS1 (FC:238.1), MTCO1P40 (FC:107.5), ATP6V1G2-DDX39B (FC:53.4), MTND4P12 (FC:34.0), RMRP (FC:30.1), while the most down regulated genes were GVINP1 (FC:-702.0), ENSG00000273217 (FC:-56.3; Rap Guanine Nucleotide Exchange Factor 6, associated with obesity and cholesterol metabolism), ENSG00000263244 (FC:-29.2; a novel transcript, 3' overlapping Chromosome 16 ORF72, associated with obesity and cholesterol metabolism), LY75-CD302 (FC:-26.5) and CXCL8 (FC:-10.6). The gene discussed is RAPGEF6; the disease is obesity due to melanocortin 4 receptor deficiency.