Of the genes that were upregulated in USA-PCa, the five most differentially expressed were: G0S2 (FC: 10.4), EGR1 (FC: 8.4), ENSG00000248993 (FC: 6.8; a novel MHC Class II Beta Chain N-Terminal Domain-Containing Protein associated with obesity), ENSG00000279753 (FC: 5.8; an uncharacterized gene associated with cholesterol metabolism) and OSM (FC: 4.4). This evidence concerns the gene G0S2 and obesity due to melanocortin 4 receptor deficiency.