In the high-risk group, most steps in the immune cycle were upregulated, including the release of cancer cell antigens (step 1), priming and activation (step 3), and trafficking of immune cells to the tumor (step 4), such as the recruitment of CD8+ T cells, macrophages, NK cells, dendritic cells (DCs), and TH17 cells (Fig. 4B). This evidence concerns the gene CD8A and neoplasm.