For our current investigation, we collected conditioned medium (CM) from BCa MCF7-Neo and MCF7-Snail overexpression cells; PCa C4-2 non-silencing (NS) and C4-2 Snail knockdown (E8) cells to determine the response of PC12 neuronal cells to the CM of cancer cell lines in the presence and the absence of Snail proteins. This evidence concerns the gene SNAI1 and posterior cortical atrophy.