The associations remained significant in a multivariate analysis after adjustment for the effects of gender and TKI type: HR = 3.53 (95% CI: 1.20-10.38), P = 0.022 for CD20+/CD8+ cell ratio in IM; and HR = 3.28 (95% CI: 1.13-9.50), P = 0.028 for CD20+/CD8+ cell ratio in OM. Here, CD8A is linked to ocular melanoma.