CD8A and renal cell carcinoma: Contradictory prognostic associations of CD8+ T cells in RCC-cc have been reported: some studies found that CD8+ T cell infiltration correlated with poor prognosis and response to immunotherapy 20, 24, 40, 58, 60, 61, whereas others reported favorable prognostic 57, 62-64 or predictive associations 46, 57, 62.