In pancreatic cancer cells, missense mutations in p53 prevent the nuclear translocation of the glycolytic enzyme 3-phosphoglyceraldehyde dehydrogenase (GAPDH) and stabilize its cytoplasmic localization, thus encouraging glycolysis in cancerous cells and obstructing apoptosis mediated by nuclear GAPDH 128. The gene discussed is GAPDH; the disease is familial pancreatic carcinoma.