Evidence from colorectal cancer and hepatocellular carcinoma supports a predominantly oncogenic role through stabilization of proliferative splicing programs (e.g., PAK5-SRSF11-HSPA12A pathway in CRC22, 70 and SRSF11-CDK1-telomerase circuits in HCC20, 76). Here, HSPA12A is linked to hepatocellular carcinoma.