FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: In parallel – but from a genetics perspective rather than immunology – Brunkow and Ramsdell discovered that a mutation in the mouse Foxp3 gene (the scurfy mutation) caused the lethal autoimmune disorder later termed IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome).