In skin barrier tissues, low‐frequency stimulation (<1 Hz) of nociceptive neurons releases CGRP, which binds RAMP1–calcitonin receptor‐like receptor (CLR) receptor complexes on DCs to promote Treg cell differentiation and suppress Th2‐mediated inflammation (e.g., in atopic dermatitis). The gene discussed is RAMP1; the disease is atopic eczema.