CHRNA7 and neoplasm: Additionally, animal models are unable to simulate the specificity of human neural innervation and the systemic metabolism of ACh, resulting in a disconnect between clinical translation (such as the effectiveness of α7‐nAChR agonists in mice but insufficient evidence in humans); the lack of dynamic tracking of the cholinergic pathway during tumor progression or PD‐1 treatment; and the absence of local delivery strategies for tumor delivery in clinical translation.