The results of the immune cell infiltration analysis showed that the infiltration abundance of immune cells, including M0 and M1 macrophage, memory B cells, plasma cells, CD8 T cells, activated CD4 T cells, follicular helper T cells, and γδT cells, was higher in the synovial membrane of patients with RA compared to that in HCs (Fig. 2A). The gene discussed is CD4; the disease is rheumatoid arthritis.