AMIGO2 and colorectal cancer: Given that focal adhesion complexes integrate cytoskeletal remodeling and motility signaling to initiate metastatic dissemination, and that AMIGO2 enhances hepatic endothelial adhesion and liver metastasis in gastric and colorectal cancers 18, 42-45, our enrichment data in PAAD extend this metastasis-associated role of AMIGO2.