Representative arrays (Fig. 2A) and quantitative analyses (Fig. 2B-C) showed that ligature-induced periodontitis (PD) elicited marked upregulation of multiple mediators at day 28 versus sham, including CINC-1 (CXCL1), CINC-2α/β (CXCL3), soluble ICAM-1 (sICAM-1), IL-1α, IL-1β, IL-1RA, LIX (CXCL5), L-selectin (CD62L), thymus chemokine (CCL25), and TIMP-1, consistent with sustained chronic gingival inflammation. The gene discussed is TIMP1; the disease is periodontitis.