Thereby, we explored if miR-497-mediated PD-L1 downregulation could alter the tumor immune microenvironment and enhance immune-mediated tumor destruction.The findings indicated that miR-497 and SK on the surface of NBs enhance immune function by activating CD8+ T cells, releasing immune inflammatory factors, and promoting the ICD of tumor cells within the tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.