KLF5 and cancer: Krüppel-like factor 5 (KLF5) is a member of the KLF family, which is defined by a conserved C-terminal zinc finger domain that confers DNA-binding specificity (3–5), and whose members function as master regulators of fundamental cellular processes including proliferation (6), apoptosis (7), angiogenesis (8), and tumorigenesis (9–11).Existing research confirms that KLFs act as a regulator, playing both driving and inhibitory roles in key steps of progression and metastasis across multiple cancers (11–14).