As depicted in Figure 3, A2AR, like its known influences on CD8 suppression, can be proactive in regulating NK functions in several ways: (i) it can suppress NK maturation, and (ii) A2AR-deficient or inhibited NK cells can enhance anti-tumor cytolytic and cytokine functions, and block CD73-mediated metastatic growth (157, 158). This evidence concerns the gene CD8A and neoplasm.