SNRPB and systemic lupus erythematosus: This model is further reinforced by findings in New Zealand white rabbits, where immunisation with PPPGMRPP triggers an initial focused response which broadens over time to include multiple epitopes across Sm B/B’ and other spliceosomes proteins such as Sm D, nRNP 70K, and nRNP A and C. Importantly, these rabbits also developed features of clinical lupus.