During the follow-up evaluation on June 20, 2022, neck CT revealed disease progression, characterized by a 50% increase in the short-axis diameter of the left supraclavicular lymph node (from baseline 10 mm to 15 mm) accompanied by elevation of tumor markers (CEA: 6.80 to 11.61 ng/mL) (Figures 1Q–T). This evidence concerns the gene CEACAM5 and neoplasm.