Increasing evidence indicates that zinc homeostasis dysregulation is a hallmark of tumor progression (9, 10), wherein aberrant zinc flux drives tumor progression by activating oncogenic pathways such as MAPK and Akt to promote oncogenesis (11–13), while simultaneously inducing epithelial-mesenchymal transition (EMT) and enhancing matrix metalloproteinase-driven extracellular matrix degradation to facilitate invasiveness and metastasis (9, 14). Here, AKT1 is linked to neoplasm.