When we analyzed the effect of sera from patients with severe COVID-19 on the TNFA gene, we noticed that there was a significant reduction in the expression of this gene (0.55 ± 0.31-fold; p <0.05) after 30 min of incubation, followed by an increase (1.15 ± 0.29-fold) equivalent to the negative control (medium; 1.09 ± 0.14-fold) after 60 min, and a new significant decrease (0.58 ± 0.38-fold; p <0.05) after 120 min (Figure 1C). The gene discussed is TNF; the disease is COVID-19.