These regulatory processes collectively support PMN formation and lay the foundation for GC peritoneal metastasis (39, 40).Additionally, macrophages are also the major sources of CXCL1 and CXCL5 in the gastric cancer microenvironment, and promote migration of gastric cancer cells through activating a CXCR2/STAT3 feed-forward loop. The gene discussed is CXCL1; the disease is gastric cancer.